Uluslararası HastaDuyurularİletişim
HACETTEPE ÜNİVERSİTESİHASTANELERİ
Randevu Al
TR
  1. Ana Sayfa
  2. Doktorlar
  3. Prof. Dr. Aytekin Akyol
Prof. Dr. Aytekin Akyol

Prof. Dr.

Aytekin Akyol

Patoloji · Erişkin Hastanesi

Gastrointestinal ve hepatobilier sistem patolojisikanserin moleküler mekanizmalarıkolorektal kanser patogenezi ve transgenik yöntemler
Randevu Al0312 305 15 55

Eğitim

  1. 2002
    Tıbbi Patoloji
    Hacettepe Üniversitesi
  2. 1997
    Tıp Fakültesi (ing)
    Hacettepe Üniversitesi
  3. 1989
    Milas Lisesi

Uzmanlık Alanları

Gastrointestinal ve hepatobilier sistem patolojisikanserin moleküler mekanizmalarıkolorektal kanser patogenezi ve transgenik yöntemler

Yayınlar

Kaynak: Hacettepe Üniversitesi Akademik Veri Yönetim Sistemi (AVESİS) · Tüm yayınlar (62) ↗

Makaleler 50

  1. AKR1B1 Expression in the Colorectal Tumor Microenvironment Contributes Towards Its Prognostic SignificanceDEMİRKOL CANLI S., GÜNER GEBEŞ G., Isik A., Sosic-Jurjevi B., Rom A. D., SEZA E. G., et al.CANCER MEDICINE, cilt.14, sa.10, 2025 (SCI-Expanded, Scopus)
  2. A new CRISPR-mediated Apc knockout allele leads to pyloric gland adenoma-like gastric polyps in mice with C57BL/6;FVB/N mixed backgroundUzun S., Ozcan O., Gok A., Isik A., Bakir S., Günel Özcan A., et al.ANIMAL MODELS AND EXPERIMENTAL MEDICINE, cilt.8, ss.922-929, 2025 (ESCI, Scopus)
  3. Post-Transcriptional Regulation of Rab7a in Lysosomal Positioning and Drug Resistance in Nutrient-Limited Cancer CellsTaskiran A. E. G., HÜSNÜGİL H. H., Soltani Z. E., Oral G., Menemenli N. S., Hampel C., et al.TRAFFIC, cilt.25, sa.9, 2024 (SCI-Expanded, Scopus)
  4. Amine Oxidase, Copper Containing 3 (Aoc3) Knockout Mice Are More Prone to DSS-induced Colitis and Colonic TumorigenesisOzcan O., AKYOL Ö., AKYOL A.IN VIVO, cilt.38, sa.5, ss.2300-2309, 2024 (SCI-Expanded, Scopus)
  5. Targeting LINC00152 activates cAMP/Ca2+/ferroptosis axis and overcomes tamoxifen resistance in ER plus breast cancerSaatci O., Alam R., Huynh-Dam K., Isik A., ÜNER M., BELDER N., et al.CELL DEATH & DISEASE, cilt.15, sa.6, 2024 (SCI-Expanded, Scopus)
  6. The Impact of Dose Rate on the Tumor Microenvironment Using Flattening-filter-free BeamsYILMAZ M., Gok A., Gedik M., ÇAĞLAYAN A., YEDEKÇİ F. Y., AYDIN DİLSİZ S., et al.Clinical Oncology, cilt.36, sa.6, ss.390-398, 2024 (SCI-Expanded, Scopus)
  7. The role of PEDF, VEGF, and Ki-67 in tissue invasion and tumor angiogenesis of medullary thyroid carcinomaKAZIMZADE G., Kurtulan O., Akyol A., Bakır S., Karakaya J., SOKMENSUER C., et al.Acta Medica, cilt.55, sa.1, ss.61-73, 2024 (TRDizin)
  8. Lysosomal alkalinization in nutrient restricted cancer cells activates cytoskeletal rearrangement to enhance partial epithelial to mesenchymal transitionHÜSNÜGİL H. H., Güleç Taşkıran A. E., GÜDERER İ., Nehri L. N., Oral G., Menemenli N. Ş., et al.Translational Oncology, cilt.41, 2024 (SCI-Expanded, Scopus)
  9. The prognostic and predictive role of class III β-Tubulin and hENT1 expression in patients with advanced pancreatic ductal adenocarcinomaSahin T., IŞIK A., Guven D., Ceylan F., BABAOĞLU B., AKYOL A., et al.Pancreatology, cilt.24, sa.2, ss.279-288, 2024 (SCI-Expanded, Scopus)
  10. Toxic PARP trapping upon cAMP-induced DNA damage reinstates the efficacy of endocrine therapy and CDK4/6 inhibitors in treatment-refractory ER+ breast cancerSaatci O., Cetin M., ÜNER M., Tokat U. M., Chatzistamou I., Ersan P. G., et al.Nature Communications, cilt.14, sa.1, 2023 (SCI-Expanded, Scopus)
  11. THE ROLE OF FIBROBLAST GROWTH FACTOR RECEPTOR-1 IN TONSILLAR HYPERTROPHYKATAR O., AKYOL A., YILMAZ T.NOBEL MEDICUS, cilt.20, sa.3, ss.173-178, 2023 (ESCI, Scopus)
  12. Claudin 18.2 Expression in Gastric Adenocarcinomas in a Large Turkish CohortIşık A., GÜNER G., Zeyneloğlu C., DEMİRKOL CANLI S., TAŞTAN H., AKYOL A.Abant Tıp Dergisi, cilt.12, sa.2, ss.122-130, 2023 (Hakemli Dergi)
  13. Characterization of the Subcellular Distribution of Phospho-β-catenin in Colorectal CancerUzun S., Isik A., KATİPOĞLU K., GÜNER G., AKYOL A.In Vivo, cilt.37, sa.4, ss.1576-1583, 2023 (SCI-Expanded, Scopus)
  14. Role of Reduced Bdnf Expression in Novel Apc Mutant Allele-induced Intestinal and Colonic Tumorigenesis in MiceGok A., Işik A., Bakir S., Uzun S., GÜNER G., Ozcan O., et al.In Vivo, cilt.37, sa.4, ss.1562-1575, 2023 (SCI-Expanded, Scopus)
  15. A Novel Gene List Identifies Tumors with a Stromal-Mesenchymal Phenotype and Worse Prognosis in Gastric CancerDemirkol Canlı S., Üner M., Kucukkaraduman B., Karaoglu D. A., Isik A., Turhan N., et al.Cancers, cilt.15, sa.11, 2023 (SCI-Expanded, Scopus)
  16. Prognostic and predictive value of tumoral DNA damage repair protein expression in patients with resected pancreatic cancerCeylan F., Guven D. C., Taban H., Aktepe O., ŞAHİN T. K., Kilickap S., et al.Clinics and Research in Hepatology and Gastroenterology, cilt.47, sa.3, 2023 (SCI-Expanded, Scopus)
  17. Gastric Carcinoma with Lymphoid Stroma: A Combination of Mismatch Repair Deficient Medullary Type and Epstein–Barr Virus-associated Gastric CarcinomasÜner M., Isık A., Oztop S., Karabulut E., Demirkol Canlı S., Akyol A.International Journal of Surgical Pathology, cilt.30, sa.6, ss.623-633, 2022 (SCI-Expanded, Scopus)
  18. Diffuse Large B-Cell Lymphoma, Epstein-Barr Virus -Positive Kappa Monotypic Plasma Cell Proliferation and Invasive Carcinoma, Developing in a Child With Defective Mismatch RepairÜNER M., Saglam A., Tukun A., Aydin B., AKYOL A., ÜNER A.PEDIATRIC AND DEVELOPMENTAL PATHOLOGY, cilt.25, sa.3, ss.339-344, 2022 (SCI-Expanded, Scopus)
  19. Loss of CTNNB1 exon 3 in sclerosing angiomatoid nodular transformation of the spleenUzun S., Ozcan O., Isik A., Saglam A., Gedikoglu G., Demiroz A. S., et al.VIRCHOWS ARCHIV, cilt.479, sa.4, ss.747-754, 2021 (SCI-Expanded, Scopus)
  20. Intrahepatic Biliary Intraductal Papillary Mucinous Neoplasm With Intermittent Jaundice: Case ReportCENNET Ö., DOĞRUL A. B., TIRNAKSIZ M. B., ÜNER H., AKYOL A., KARÇAALTINCABA M., et al.INTERNATIONAL SURGERY, cilt.105, sa.1-3, ss.211-214, 2021 (SCI-Expanded, Scopus)
  21. Enhanced expression of HNF4 alpha during intestinal epithelial differentiation is involved in the activation of ER stressTunçer S., Sade-Memişoğlu A., Keşküş A., Sheraj I., Güner G., Akyol A., et al.FEBS JOURNAL, cilt.287, sa.12, ss.2504-2523, 2020 (SCI-Expanded, Scopus)
  22. A Highly Potent TACC3 Inhibitor as a Novel Anticancer Drug Candidate.Akbulut O., Lengerli D., Saatci O., Duman E., Seker U., Isik A., et al.Molecular cancer therapeutics, cilt.19, ss.1243-1254, 2020 (SCI-Expanded, Scopus)
  23. Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancerSaatci O., Kaymak A., Raza U., Ersan P., Akbulut O., Banister C., et al.NATURE COMMUNICATIONS, cilt.11, sa.1, 2020 (SCI-Expanded, Scopus)
  24. The potential efficacy of dietary fatty acids and fructose induced inflammation and oxidative stress on the insulin signaling and fat accumulation in miceTamer F., Ulug E., Akyol A., Nergiz-Unal R.FOOD AND CHEMICAL TOXICOLOGY, cilt.135, 2020 (SCI-Expanded, Scopus)
  25. Class III beta-tubulin Expression in Colorectal Neoplasms Is a Potential Predictive Biomarker for Paclitaxel ResponseOztop S., IŞIK A., GUNER G., Gurdal H., KARABULUT E., Yilmaz E., et al.ANTICANCER RESEARCH, cilt.39, sa.2, ss.655-662, 2019 (SCI-Expanded, Scopus)
  26. An immunohistochemical approach to detect oncogenic CTNNB1 mutations in primary neoplastic tissuesAKYOL A., GUNER G., OZSEKER H. S., IŞIK A., Atci O., UZUN S., et al.LABORATORY INVESTIGATION, cilt.99, sa.1, ss.128-137, 2019 (SCI-Expanded, Scopus)
  27. Morphologic and Immunohistochemical Appraisal of Primary Gastric CarcinomasGUNER G., IŞIK A., KARABULUT E., GEDIKOGLU G., SÖKMENSÜER C., AKYOL A.APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, cilt.26, sa.10, 2018 (SCI-Expanded, Scopus)
  28. Undifferentiated Embryonal Sarcoma of the Liver in an Adult PatientBeksac K., Mammadov R., Ciftci T., GÜNER G., AKYOL A., Kaynaroglu V.CUREUS, cilt.10, sa.7, 2018 (ESCI)
  29. Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancerSaatci O., BORGONI S., Akbulut O., Durmus S., Raza U., Eyupoglu E., et al.ONCOGENE, cilt.37, sa.17, ss.2251-2269, 2018 (SCI-Expanded, Scopus)
  30. Diagnostic and Treatment Reproducibility of Cervical Intraepithelial Neoplasia / Squamous Intraepithelial Lesion and Factors Affecting the DiagnosisSAGLAM A., USUBÜTÜN A., DOLGUN A., Mutter G. L., SALMAN M. C., KURTULAN O., et al.TURKISH JOURNAL OF PATHOLOGY, cilt.33, sa.3, ss.177-191, 2017 (ESCI, Scopus, TRDizin)
  31. Azelnidipine, a novel calcium channel blocker, ameliorates severity of colitis in DSS induced colitis in mice possibly by modulating tissue levels of TNF-alpha and IL-6Kav T., AKYOL A., Aksoy E., Ozer C., Torgutalp M., Sivri B.JOURNAL OF CROHNS & COLITIS, cilt.11, 2017 (SCI-Expanded, Scopus)
  32. Herediter Mide KanserleriGüner G., AKYOL A.Güncel Gastroenteroloji, cilt.21, sa.1, ss.38-44, 2017 (Hakemli Dergi)
  33. Cyanoacrylate Associated Foreign Body Granulomatous Gastritis: A Report of Three CasesGÜNER G., KURTULAN O., KAV T., SÖKMENSÜER C., Gedikoglu G., AKYOL A.CASE REPORTS IN PATHOLOGY, 2017 (ESCI)
  34. The prognostic significance of Cerb-B2 expression in gastric carcinomasBabaoglu B., AKYOL A., Sokmensuer C., Gedikoglu G.VIRCHOWS ARCHIV, cilt.469, 2016 (SCI-Expanded, Scopus)
  35. Evaluation of prognostic value of 2010 WHO classification of gastric neuroendocrine tumoursKurtulan O., Turhan N., AKYOL A., Gedikoglu G., Sokmensuer C.VIRCHOWS ARCHIV, cilt.469, 2016 (SCI-Expanded, Scopus)
  36. Kolorektal Kanserdeki BiyobelirteçlerAKYOL A.Güncel Gastroenteroloji, cilt.20, sa.2, ss.120-129, 2016 (Hakemli Dergi)
  37. Image of the Month: A Neuroendocrine Tumor Invading All Portal Venous System Components.Ozturk O., Bayraktar Y., Akyol A.The American journal of gastroenterology, cilt.111, ss.311, 2016 (SCI-Expanded, Scopus)
  38. Tissue-Specific Effects of Reduced β-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium.Feng Y., Sakamoto N., Wu R., Liu J., Wiese A., Green M., et al.PLoS genetics, cilt.11, 2015 (SCI-Expanded, Scopus)
  39. Morphological analysis of the relationship between the duodenal biopsy samples diagnosed as "increased intraepithelial lymphocytes" with Helicobacter pylori gastritis and Celiac DiseaseBabaoglu B., Ozturk O., AKYOL A., Koklu S., Sokmensuer C.VIRCHOWS ARCHIV, cilt.467, 2015 (SCI-Expanded, Scopus)
  40. Histopathological Evaluation of Orchiectomy Specimens in 51 Late Postpubertal Men with Unilateral CryptorchidismKoni A., Ozseker H. S., Arpali E., Kilinc E., DOĞAN H. S., AKYOL A., et al.JOURNAL OF UROLOGY, cilt.192, sa.4, ss.1183-1188, 2014 (SCI-Expanded, Scopus)
  41. Intraductal Papillary Mucinous Neoplasms of the Pancreas (IPMNs): 11 cases of Hacettepe experienceBugdayci M., AKYOL A., SÖKMENSÜER C., Gedikoglu G.VIRCHOWS ARCHIV, cilt.465, 2014 (SCI-Expanded, Scopus)
  42. Maternal Cdx2 is dispensable for mouse developmentBlij S., Frum T., Akyol A., Fearon E., Ralston A.DEVELOPMENT, cilt.139, sa.21, ss.3969-3972, 2012 (SCI-Expanded, Scopus)
  43. Reproducibility of endometrial intraepithelial neoplasia diagnosis is good, but influenced by the diagnostic style of pathologistsUSUBÜTÜN A., Mutter G. L., Saglam A., Dolgun A., Ozkan E. A., Ince T., et al.MODERN PATHOLOGY, cilt.25, sa.6, ss.877-884, 2012 (SCI-Expanded, Scopus)
  44. CDX2 Regulates Multidrug Resistance 1 Gene Expression in Malignant Intestinal EpitheliumTakakura Y., Hinoi T., Oue N., Sasada T., Kawaguchi Y., Okajima M., et al.CANCER RESEARCH, cilt.70, sa.17, ss.6767-6778, 2010 (SCI-Expanded, Scopus)
  45. Generating somatic mosaicism with a Cre recombinase - microsatellite sequence transgeneAkyol A., Hinoi T., Feng Y., Bommer G. T., Glaser T. M., Fearon E. R.NATURE METHODS, cilt.5, sa.3, ss.231-233, 2008 (SCI-Expanded, Scopus)
  46. Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivationHinoi T., Akyol A., Theisen B. K., Ferguson D. O., Greenson J. K., Williams B. O., et al.CANCER RESEARCH, cilt.67, sa.20, ss.9721-9730, 2007 (SCI-Expanded, Scopus)
  47. Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathwaysWu R., Hendrix-Lucas N., Kuick R., Zhai Y., Schwartz D. R., Akyol A., et al.CANCER CELL, cilt.11, sa.4, ss.321-333, 2007 (SCI-Expanded, Scopus)
  48. Drosophila split ends homologue SHARP functions as a positive regulator of wnt/beta-catenin/T-cell factor signaling in neoplastic transformationFeng Y., Bommer G. T., Zhai Y., Akyol A., Hinoi T., Winer I., et al.CANCER RESEARCH, cilt.67, sa.2, ss.482-491, 2007 (SCI-Expanded, Scopus)
  49. CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epitheliumHINOI T., GESINA G., Akyol A., KUICK R., HANASH S., GIORDANO T., et al.GASTROENTEROLOGY, cilt.128, sa.4, ss.946-961, 2005 (SCI-Expanded, Scopus)
  50. Myasthenia gravis and lymphoblastic lymphoma involving the thymus: A rare associationUner A., Abali H., Engin H., Akyol A., Ruacan E., Tan E., et al.LEUKEMIA & LYMPHOMA, cilt.42, sa.3, ss.527-531, 2001 (SCI-Expanded, Scopus)

Hakemli Bilimsel Toplantılarda Yayımlanmış Bildiriler 11

  1. Azelnidipine, a novel calcium channel blocker, ameliorates severity of colitis in DSS induced colitis in mice possibly by modulating tissue levels of TNF-alpha and IL-6KAV T., AKYOL A., KAHRAMANOĞLU AKSOY E., ÖZER C., TORGUTALP M., SİVRİ B.12th Congress of ECCO, Barselona, İspanya, 15 Şubat 2017 - 18 Şubat 2018, cilt.11, ss.93-94, (Özet Bildiri)
  2. Class III Beta-Tubulin Expression in Colrectal Cancer Developmentöztop s., IŞIK A., taş g. g., YILMAZ E., AKYOL A.IONCC 2017, 21 - 23 Eylül 2017, (Özet Bildiri)
  3. Granülomatöz Gastrit 17 Olgu ile Hacettepe DeneyimiKurtulan O., AKYOL A., SÖKMENSÜER C., GEDİKOĞLU M. G.26. Ulusal Patoloji Kongresi, Antalya, Türkiye, 2 - 06 Kasım 2016, (Özet Bildiri)
  4. Evaluation of prognostic value of 2010 WHO classification of gastric neuroendocrine tumoursKurtulan O., Turhan N., AKYOL A., GEDİKOĞLU M. G., SÖKMENSÜER C.28th European Congress of Pathology, Cologne, Almanya, 25 - 29 Eylül 2016, (Özet Bildiri)
  5. The prognostic significance of Cerb B2 expression in gastric carcinomasBabaoğlu B., AKYOL A., SÖKMENSÜER C., GEDİKOĞLU M. G.28th European Congress of Pathology, Cologne, Almanya, 25 - 29 Eylül 2016, (Özet Bildiri)
  6. DNA hatalı eşleşme tamir mekanizması bozukluğu içeren kolorektal kanserlerin dörtlü immünohistokimyasal panel ile değerlendirilmesiAKYOL A., Üner M., Işık A., Öztop S., GEDİKOĞLU M. G., SÖKMENSÜER C.25. Ulusal Patoloji Kongresi, Türkiye, 14 - 17 Ekim 2015, (Özet Bildiri)
  7. İleri evre medüller tip mide karsinomlarının klinikopatolojik ve moleküler özellikleriÜner M., Güner G., Işık A., Karabulut E., GEDİKOĞLU M. G., SÖKMENSÜER C., et al.25. Ulusal Patoloji Kongresi, Türkiye, 14 - 17 Ekim 2015, (Özet Bildiri)
  8. Morphological analysis of the relationship between the duodenal biopsy samples diagnosed as increased intraepithelial lymphocytes with Helicobacter pylori gastritis and Celiac DiseaseBabaoğlu B., Ozturk Ö., AKYOL A., KÖKLÜ S., SÖKMENSÜER C.27th European Congress of Pathology, 5 - 09 Ekim 2015, cilt.467, ss.130, (Özet Bildiri)
  9. Overcoming chemotherapy resistance in triple negative breast cancer via targeting lysyl oxidase (LOX)Saatçi Ö., Akbulut Ö., Rezaeain A., Banister C., Sikirzhytski V., AKSOY S., et al.
  10. Heterocyclic amine intake along with high fat diet may trigger predisposition to atherosclerosisYuruk A., GÜMÜŞ D., AKYOL A., KIZIL M., NERGİZ ÜNAL R.
  11. Class III Beta-Tubulin Expression in Colorectal Cancer DevelopmentÖztop S., Işık A., Güner Taş G., YILMAZ E., AKYOL A.

Kitaplar 1

  1. Mide kanseri ve prekürsör lezyonlar: Güncel ve moleküler sınıflama.GÜNER TAŞ G., AKYOL A., GÜNER G.

İletişim

Telefon
0312 305 15 55
Bölüm
Patoloji, Erişkin Hastanesi
Konuştuğu diller
İngilizce

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