Emine Eren Koçak

Dr. Emine Eren-Koçak was graduated from Hacettepe University Faculty of Medicine in 2000. She completed her Psychiatry residency training at Başkent Universty, Faculty of Medicine between years 2000 and 2005. On 2005, she started the Neuroscience PhD program at Institute of Neurological Sciences and Psychiatry. She worked 2 years for her dissertation thesis at University of Michigan, at Huda Akil’s Laboratory and completed her PhD degree on 2009.

She received Project Support Award of Brain Research Society and Project Support Award of Psychiatric Association of Turkey on 2005. She won Novartis Foundation bursary on 2007, with which she worked at University of Michigan, MBNI. In 2007, she won a scholarship for the the fellowship program for integrated doctoral studies of Turkish Academy of Sciences. She continued her work at University of Michigan by this scholarship. Her Project entitled “The relationship between GFG (FGF2-AS) levels and depression- and anxiety-like behavior in rats and investigation of antidepressant action of GFG inhibition by RNA interference” was supported by NationalYoung Researchers Carrier Development Program of the Scientific and Technological Research Council of Turkey.

She is currently working at Institute of Neurological Sciences and Department of Psychiatry at Hacettepe University.

1. Biallelic ATG9B Variants Define a Novel Autophagy-Related Neurodevelopmental Disorder with Cerebellar AtaxiaKılıç S., ESMEN K., Méreaux J., Oto A. M., Kose T. B., SEVER BAHÇEKAPILI M., et al.Genes, cilt.17, sa.6, 2026 (SCI-Expanded, Scopus)
2. Twelve-Month Use of Mental Health Services: Results from the World Mental Health Türkiye Survey Türkiye’de On İki Aylık Ruh Sağlığı Hizmeti Kullanımı: Türkiye Ruh Sağlığı Profili-2 Araştırması SonuçlarıKILIÇ C., Uluğ Ö. Ş., BAĞCAZ A., Ulusoy Kaymak S., Zhang A., AK S., et al.Turk Psikiyatri Dergisi, cilt.37, ss.192-204, 2026 (SSCI, Scopus)
3. Prevalence, Persistence, and Severity of 12-Month and 30-Day DSM-5 Disorders in the Turkish World Mental Health Survey Türkiye Ruh Sağlığı Profili-2 Araştırması’nda 12 Aylık ve 30 Günlük DSM-5 Bozukluklarının Yaygınlığı, Süregenliği ve ŞiddetiKILIÇ C., Üstün B., Uluğ Ö. Ş., AK S., Ulusoy M., Kamişli S., et al.Turk Psikiyatri Dergisi, cilt.37, ss.180-191, 2026 (SSCI, Scopus)
4. Sex-Specific Reversal of Stress-Induced Depressogenic Behaviors by Inhibition of HMGB1, TLR4, and NF-κB SignalingBAHADIR VAROL A., Solgun B., Küreli G., Esen E. C., EREN KOÇAK E.Molecular Neurobiology, cilt.63, sa.1, 2026 (SCI-Expanded, Scopus)
5. Layer-specific input to medial prefrontal cortex is linked to stress susceptibilitySolakoglu S. T., ERDENER Ş. E., Gliko O., CAN A., Sumbul U., EREN KOÇAK E.TRANSLATIONAL PSYCHIATRY, cilt.15, sa.1, 2025 (SCI-Expanded, Scopus)
6. Attention-related impairment and contributing neuroinflammatory signalling in the prefrontal cortex of perinatal nicotine-exposed miceUYGUN S. D., Kose T. B., BAHADIR VAROL A., Uzay B., EREN KOÇAK E.ACTA NEUROPSYCHIATRICA, cilt.37, 2025 (SCI-Expanded, Scopus)
7. Morphological Correlates of Behavioral Variation in Autism Spectrum Disorder Groups in A Maternal Immune Activation ModelÜNAL D., Bahadir Varol A., Kose T. B., EREN KOÇAK E.NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, cilt.61, sa.3, ss.195-201, 2024 (SCI-Expanded, Scopus, TRDizin)
8. FGF2 gene's antisense protein, NUDT6, plays a depressogenic role by promoting inflammation and suppressing neurogenesis without altering FGF2 signallingUzay B., Bahadır-Varol A., Hökelekli F. Ö., YILMAZ M., Esen E. C., BAŞAR K., et al.Journal of Physiology, cilt.602, sa.7, ss.1427-1442, 2024 (SCI-Expanded, Scopus)
9. Cortical spreading depression can be triggered by sensory stimulation in primed wild type mouse brain: a mechanistic insight to migraine aura generationHANALİOĞLU Ş., TAŞKIRAN SAĞ A., KARATAŞ KURŞUN H., Donmez-Demir B., YILMAZ ÖZCAN S., EREN KOÇAK E., et al.JOURNAL OF HEADACHE AND PAIN, cilt.23, sa.1, 2022 (SCI-Expanded, Scopus)
10. NF-KB and HMGB1 Differentially Mediate Effects of Acute Predator Stress on Anhedonia and Behavioral DespairBahadir-Varol A., Kureli G., EREN KOÇAK E.BIOLOGICAL PSYCHIATRY, cilt.91, sa.9, 2022 (SCI-Expanded, Scopus)
11. The Role of NUDT6 and S100A9 as New Molecular Players in Hippocampus, Basolateral Amygdala and Prefrontal Cortex in a Post-Traumatic Stress Disorder (PTSD) ModelUzay B., BELDER N., EREN KOÇAK E.BIOLOGICAL PSYCHIATRY, cilt.91, sa.9, 2022 (SCI-Expanded, Scopus)
12. cAMP/PKA-CREB-BDNF signaling pathway in hippocampus of rats subjected to chemically-induced phenylketonuriaCicek C., Eren-Koçak E., Telkoparan-Akillilar P., Gok M., Bodur E.METABOLIC BRAIN DISEASE, cilt.37, sa.2, ss.545-557, 2022 (SCI-Expanded, Scopus)
13. Ion Channel Dysfunction and Neuroinflammation in Migraine and DepressionEren-Kocak E., DALKARA T.FRONTIERS IN PHARMACOLOGY, cilt.12, 2021 (SCI-Expanded, Scopus)
14. Brain glycogen metabolism: A possible link between sleep disturbances, headache and depressionPetit J., Eren-Koçak E., Karatas H., Magistretti P., Dalkara T.SLEEP MEDICINE REVIEWS, cilt.59, 2021 (SCI-Expanded, Scopus)
15. The Effects of P2X7 Antagonism on Neuroinflammation Following Optogenetically-Triggered Cortical Spreading DepressionUzay B., Donmez-Demir B., Yilmaz-Ozcan S., Eren-Kocak E., Yemisci M., Dalkara T., et al.JOURNAL OF HEADACHE AND PAIN, cilt.22, sa.SUPPL 1, ss.14, 2021 (SCI-Expanded, Scopus)
16. The Effects of P2X7 Antagonism on Neuroinflammation Following Optogenetically-Triggered Cortical Spreading DepressionUzay B., Donmez-Demir B., Yilmaz-Ozcan S., Eren-Kocak E., Yemisci M., Dalkara T., et al.CEPHALALGIA, cilt.41, sa.1_SUPPL, ss.20, 2021 (SCI-Expanded, Scopus)
17. The Effect of P2X7 Antagonism on Subcortical Spread of Optogenetically-Triggered Cortical Spreading DepressionUzay B., Donmez-Demir B., Yilmaz-Ozcan S., Eren-Kocak E., Ozkan M., Dalkara T., et al.EUROPEAN JOURNAL OF NEUROLOGY, cilt.28, ss.308, 2021 (SCI-Expanded, Scopus)
18. Effect of FGF-AS Modulation on Neurogenesis in Rat HippocampusUzay B., EREN KOÇAK E.BIOLOGICAL PSYCHIATRY, cilt.89, sa.9, 2021 (SCI-Expanded, Scopus)
19. Nuclear expansion and pore opening are instant signs of neuronal hypoxia and can identify poorly fixed brainsDEHGHANI A., Karatas H., CAN A. B., ERDEMLI E., YEMISCI M., EREN-KOCAK E., et al.SCIENTIFIC REPORTS, cilt.8, 2018 (SCI-Expanded, Scopus)
20. Stress modulates cortical excitability via alpha-2 adrenergic and glucocorticoid receptors: As assessed by spreading depressionYapici-Eser H., DONMEZ-DEMİR B. N., Kilic K., Eren-Kocak E., DALKARA T.EXPERIMENTAL NEUROLOGY, cilt.307, ss.45-51, 2018 (SCI-Expanded, Scopus)
21. Striatal Neurotransmitter Release-related Presynaptic Proteins in L-dopa Induced Dyskinesia in a Model of ParkinsonismYALÇIN ÇAKMAKLI G., VURAL A., EREN KOÇAK E., ELİBOL B., Saka E.NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, cilt.55, sa.1, ss.73-79, 2018 (SCI-Expanded, Scopus, TRDizin)
22. Brain Peptides for the Treatment of Neuropsychiatric DisordersKaratas H., YEMISCI M., EREN-KOCAK E., DALKARA T.CURRENT PHARMACEUTICAL DESIGN, cilt.24, sa.33, ss.3905-3917, 2018 (SCI-Expanded, Scopus)
23. Inadequate Brain Glycogen or Sleep Increases Spreading Depression SusceptibilityKILIÇ K., Karatas H., DONMEZ-DEMİR B. N., Eren-Kocak E., Gursoy-Ozdemir Y., Can A., et al.ANNALS OF NEUROLOGY, cilt.83, sa.1, ss.61-73, 2018 (SCI-Expanded, Scopus)
24. Cognitive Dysfunctions in Posttraumatic Stress DisorderEREN KOÇAK E., KILIÇ C.TURK PSIKIYATRI DERGISI, cilt.28, sa.2, ss.124-131, 2017 (SSCI, Scopus, TRDizin)
25. A Simple Extraction Procedure for HPLC Analysis of Fluoxetine in Rat Plasma SamplesREÇBER T., Ozkan E., Eren-Kocak E., YILMAZ M., NEMUTLU E., KIR S.CURRENT PHARMACEUTICAL ANALYSIS, cilt.13, sa.1, ss.80-84, 2017 (SCI-Expanded, Scopus)
26. Dysregulated fibroblast growth factor (FGF) signaling in neurological and psychiatric disordersTurner C. A., Eren-Kocak E., Inui E. G., Watson S. J., Akil H.SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, cilt.53, ss.136-143, 2016 (SCI-Expanded, Scopus)
27. Posttraumatic Growth After Earthquake Trauma is Predicted by Executive Functions A Pilot StudyEren-Kocak E., KILIÇ C.JOURNAL OF NERVOUS AND MENTAL DISEASE, cilt.202, sa.12, ss.859-863, 2014 (SCI-Expanded, SSCI, Scopus)
28. Effects of Acute and Chronic Electroconvulsive Shocks on Glycogen Synthase Kinase 3[beta] Level and Phosphorylation in MiceBAŞAR K., Eren-Kocak E., Ozdemir H., ERTUĞRUL A.JOURNAL OF ECT, cilt.29, sa.4, ss.261-266, 2013 (SCI-Expanded, SSCI, Scopus)
29. The role of fibroblast growth factor antisense in modulation of affective behaviourEREN-KOCAK E., YILMAZ M., BAŞAR K., AYHAN Y., Ozdemir H., ŞEN Z.EUROPEAN NEUROPSYCHOPHARMACOLOGY, cilt.23, 2013 (SCI-Expanded, Scopus)
30. Spreading Depression Triggers Headache by Activating Neuronal Panx1 ChannelsKARATAS H., ERDENER Ş. E., GURSOY-OZDEMIR Y., Lule S., EREN-KOCAK E., Sen Z. D., et al.SCIENCE, cilt.339, sa.6123, ss.1092-1095, 2013 (SCI-Expanded, Scopus)
31. Psychiatric Disorders and EpigeneticsKOCAK E., ERTUĞRUL A.TURK PSIKIYATRI DERGISI, cilt.23, sa.2, ss.130-140, 2012 (SSCI, Scopus, TRDizin)
32. Short-Hairpin RNA Silencing of Endogenous Fibroblast Growth Factor 2 in Rat Hippocampus Increases Anxiety BehaviorEREN KOÇAK E., Turner C. A., Watson S. J., Akil H.BIOLOGICAL PSYCHIATRY, cilt.69, sa.6, ss.534-540, 2011 (SCI-Expanded, Scopus)
33. Memory and prefrontal functions in earthquake survivors: differences between current and past post-traumatic stress disorder patientsEren-Kocak E., KILIÇ C., Aydin I., Hizli F. G.ACTA PSYCHIATRICA SCANDINAVICA, cilt.119, sa.1, ss.35-44, 2009 (SCI-Expanded, SSCI, Scopus)

1. Kronik stresin bellek üzerine etkileri dişi ile erkek farelerde farklı mı?ESEN E. C., YALÇIN ÇAKMAKLI G., KARATAŞ KURŞUN H., YEMİŞCİ ÖZKAN M., DALKARA T., ELİBOL B., et al.Ulusal Sinirbilim Kongresi, Türkiye, 07 Kasım 2020, (Özet Bildiri)
2. The Role of AAV-Mediated FGF-AS Overexpression in Neuroinflammation in Rat HippocampusUzay B., DALKARA T., EREN KOÇAK E.75th Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP), New York, Amerika Birleşik Devletleri, 30 Nisan - 02 Mayıs 2020, cilt.87, (Özet Bildiri)
3. Changes in hippocampal cholinergic system in an experimental rat Phenylketonuria modelÇİÇEK Ç., AKTAN O., GÖK M., ÇAKIR AKTAŞ C., EREN KOÇAK E., BODUR E.XVIth International Symposium on Cholinergic Mechanisms (ISCM-XVI), Rekhovot, İsrail, 8 - 13 Aralık 2019, (Özet Bildiri)
4. The role of 12/15 lipoxygenase inhibition on stroke induced neuroinflammationÇAKIR AKTAŞ C., YEMİŞCİ ÖZKAN M., EREN KOÇAK E., DALKARA T., BODUR E., van Leyen K., et al.Society for Neuroscience, 19 - 23 Ekim 2019, (Özet Bildiri)
5. Inhibition of retinal and cerebral microvascular glycogen utilization promotes capillary constrictions in miceYemisci M., Uruk G., Yilmaz-Ozcan S., Donmez-Demir B., Karatas-Kursun H., Eren-Kocak E., et al.29th International Symposium on Cerebral Blood Flow, Metabolism and Function / 14th International Conference on Quantification of Brain Function with PET (BRAIN and BRAIN Pet), Yokohama, Japonya, 4 - 07 Temmuz 2019, cilt.39, ss.288-289, (Özet Bildiri)
6. Cortical spreading depression induces expression of BDNF and pro-BDNF proteins, which may impact neuroinflammationYemisci M., Senel B., Yilmaz-Ozcan S., Donmez-Demir B., Karatas-Kursun H., Eren-Kocak E., et al.29th International Symposium on Cerebral Blood Flow, Metabolism and Function / 14th International Conference on Quantification of Brain Function with PET (BRAIN and BRAIN Pet), Yokohama, Japonya, 4 - 07 Temmuz 2019, cilt.39, ss.519-520, (Özet Bildiri)
7. Molecular Motor Mechanism of Contraction in Central Nervous System PericytesKÜRELİ G., YILMAZ ÖZCAN S., CAN A., DEMİR B. N., YEMİŞCİ ÖZKAN M., KARATAŞ KURŞUN H., et al.17. Ulusal Sinirbilim Kongresi, Trabzon, Türkiye, 04 Nisan 2019, (Özet Bildiri)
8. Merkezi sinir sistemi perisitlerinde kasılmanın moleküler mekanizmasıKÜRELİ G., YILMAZ ÖZCAN S., CAN A., DEMİR B. N., YEMİŞCİ ÖZKAN M., KARATAŞ KURŞUN H., et al.17. Ulusal Sinirbilim Kongresi, Türkiye, 4 - 07 Nisan 2019, (Özet Bildiri)
9. Hippocampal FGF-antisense overexpression increase depression-like behaviour in the ratUzay B., Karatas-Kursun H., Yemisci M., DALKARA T., Eren-Kocak E.31st Congress of the European-College-of-Neuropsychopharmacology (ECNP), Barcelona, İspanya, 6 - 09 Ekim 2018, cilt.29, (Özet Bildiri)
10. Lipooksijenaz inhibisyonunun kalıcı serebral iskemi modelinde oluşan nöroinflamasyon üzerine etkisiCanan A. Ç., BODUR E., YEMİŞCİ ÖZKAN M., EREN KOÇAK E., Van Leyen K., DALKARA T., et al.16. ULUSAL SİNİRBİLİM KONGRESİ, 20-23 Mayıs 2018, İTÜ Ayazağa Kampüsü, İstanbul., İstanbul, Türkiye, 20 - 23 Mayıs 2018, (Özet Bildiri)
11. Effect of Hippocampal Overexpression of a Natural Antisense protein, FGF­AS, on Learning and Memoryuzay b., KARATAŞ KURŞUN H., YEMİŞCİ ÖZKAN M., DALKARA T., EREN KOÇAK E.73rd Annual Meeting of Society of Bİological Paychiatry, 10 Mayıs 2018, (Özet Bildiri)
12. Migren Araştırmaları için yeni bir kortikal yayılan depresyona yatkınlık modeli: Na-K ATPaz A-2 RNA İnterferansıTAŞKIRAN SAĞ A., Yılmaz Özcan S., KARATAŞ KURŞUN H., DEMİR B. N., Hanalioğlu Ş., EREN KOÇAK E., et al.53. Ulusal Nöroloji Kongresi, Türkiye, 25 - 29 Kasım 2017, (Özet Bildiri)
13. Fluorescent biomarkers as reporters of poor quality transcardial perfusion-fixation in frozen brain sections: A much needed tool for experimental neuroscience.Dehghani A., KARATAŞ KURŞUN H., CAN A., YEMİŞCİ ÖZKAN M., EREN KOÇAK E., DALKARA T.Society for Neuroscience Annual Meeting, 11 - 15 Kasım 2017, (Özet Bildiri)
14. 12/15 lipoxygenase inhibition suppresses neuroinflammation in a thrombotic permanent cerebral ischemia modelCakir-Aktas C., Yemisci M., BODUR E., Eren-Kocak E., van Leyen K., DALKARA T., et al.23rd World Congress of Neurology (WCN), Kyoto, Japonya, 16 - 21 Eylül 2017, cilt.381, ss.863-864, (Özet Bildiri)
15. 12/15 Lipoxygenase Inhibition Supresses Neuroinflammation in a Thrombotic Permanent Cerebral Ischemia ModelÇakır Aktaş C., YEMİŞCİ ÖZKAN M., BODUR E., EREN KOÇAK E., van L. K., DALKARA T., et al.WCN 2017, Kyoto, Japonya, 16 - 22 Eylül 2017, cilt.381, ss.863-864, (Özet Bildiri)
16. 12/15 Lipoxygenase Inhibition Suppresses Neuroinflammation in aThrombotic Permanent Cerebral Ischemia Model.Çakır Aktaş C., YEMİŞCİ ÖZKAN M., BODUR E., EREN KOÇAK E., van Leyen K., DALKARA T., et al.XXIII World Congress of Neurology, 16 - 21 Eylül 2017, (Özet Bildiri)
17. FGF-AS Overexpression in Medial Prefrontal Cortex Regulates Anxiety-like Behavior in RatsEREN KOÇAK E., HÖKELEKLİ F. Ö., KARATAŞ KURŞUN H., YEMİŞCİ ÖZKAN M., DALKARA T.30th ECNP Congress, 2 - 05 Eylül 2017, (Özet Bildiri)
18. The Effect of NUDT6 Expression on Contextual Learning Assessed by Passive Avoidance TestHökelekli F. Ö., Yımaz M., ESEN E. C., BAŞAR K., AYHAN Y., DALKARA T., et al.Annual Meeting of American Psychiatric Association, 20 - 24 Mayıs 2017, (Özet Bildiri)
19. Investigation of a marker for the quality of transcardial perfusion in frozen brain sections is miceDehghani A., KARATAŞ KURŞUN H., CAN A., YEMİŞCİ ÖZKAN M., EREN KOÇAK E., DALKARA T.15. Ulusal Sinirbilim Kongresi, 7 - 10 Mayıs 2017, cilt.11, ss.35, (Özet Bildiri)
20. Lipoksijenaz İnhibisyonunun Akut Geçici Serebral İskemi/Rekanalizasyon Modelinde Gelişen Nöroinflamasyona Etkisiçakır aktaş C., YEMİŞCİ ÖZKAN M., BODUR E., EREN KOÇAK E., van Leyen K., DALKARA T., et al.15.Ulusal Sinirbilim Kongresi, 7 - 10 Mayıs 2017, (Özet Bildiri)
21. Role of a Natural Antisense Transcript, FGF2-AS, in Affective BehaviorHokelekli F. O., YILMAZ M., BAŞAR K., AYHAN Y., DALKARA T., EREN KOÇAK E.72nd Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP), California, Amerika Birleşik Devletleri, 18 - 20 Mayıs 2017, cilt.81, (Özet Bildiri)
22. Cortical spreading depression can be triggered by photic stimulation in susceptible mouse brainHanalioğlu S., Taskıran Sag A., KARATAŞ KURŞUN H., Eren Kocak E., Yemisci Ozkan M., GURSOY OZDEMİR Y., et al.FENS, 2 - 06 Temmuz 2016, (Özet Bildiri)
23. Depresyon nörobiyolojisinde yeni bir molekül GFGEREN KOÇAK E., BAŞAR K., AYHAN Y., YILMAZ M.50. Ulusal Psikiyatri Kongresi, Antalya, Türkiye, 12 - 16 Kasım 2014, cilt.25, ss.5-6
24. The fole of FGF2 AS in stress and depression like behavior in ratsEREN KOÇAK E., BAŞAR K., YILMAZ M., AYHAN Y., DALKARA T.Annual Meeting of Society for Neuroscience, San Diego, Amerika Birleşik Devletleri, 9 - 13 Kasım 2013
25. Striatal neurotransmitter release-related presynaptic proteins in L-dopa induced dyskinesia in 6-hydroxydopamine model of parkinsonismYALÇIN ÇAKMAKLI G., VURAL A., EREN KOÇAK E., ELİBOL B., SAKA TOPÇUOĞLU E.14th International Congress of Parkinson’s Disease and Movement Disorders, Buenos Aires, Arjantin, 13 - 17 Haziran 2010, (Özet Bildiri)
26. Tenses can have different effects on declarative processesKocak O. M., Yuksel S., Yilmaz A., Eren-Kocak E., Sayar K.22nd Congress of the European-College-of-Neuropsychopharmacology, İstanbul, Türkiye, 12 - 16 Eylül 2009, cilt.19, (Özet Bildiri)
27. Sıçanda L-dopa diskinezi modelinde striatal presinaptik proteinlerin ekspresyonuYALÇIN ÇAKMAKLI G., EREN KOÇAK E., ELİBOL B., SAKA TOPÇUOĞLU E.43. Ulusal Nöroloji Kongresi, Antalya, Türkiye, 10 - 15 Kasım 2007, cilt.13, ss.89, (Özet Bildiri)
28. Effects of chronic electroconvulsive shock on glycogen synthase kinase 3 beta protein level and phosphorylation pattern in hippocampus and frontal lobeBAŞAR K., EREN KOÇAK E., DALKARA T., REZAKİ M.15. CINP (International College of Neuropsychopharmacology) Congress, Şikago, Amerika Birleşik Devletleri, 9 - 13 Temmuz 2006, cilt.9, ss.178
29. Cerebral peri-microvascular glycogen utilization has a role in endothelium-pericyte interaction in miceURUK G., YILMAZ ÖZCAN S., DEMİR B. N., KARATAŞ KURŞUN H., EREN KOÇAK E., DURAN J., et al.
30. Resolution of neuroinflammation triggered by cortical spreading depressionKAYA Z., BELDER N., YILMAZ ÖZCAN S., DEMİR B. N., EREN KOÇAK E., KARATAŞ KURŞUN H., et al.
31. NUDT6 Aşırı İfadesi ile Dendritik Çıkıntı Sayısı İlişkisiHökelekli F. Ö., Yılmaz M., ESEN E. C., BAŞAR K., AYHAN Y., DALKARA T., et al.