Immunology Laboratory

The designation cryoglobulin and criofibrinogen that are the proteins settle in cold is performed in immunology laboratory. These are the laboratory analyses that helps diagnosing vasculitis or glomerulonephritis diseases, in individuals who have circulatory problems on skin, particularly on arms and legs, when they are exposed to cold.

How is the test performed

Cryoglobulin designation is the method of defining monoclonal or polyclonal (immunoglobulin) proteins that settle when cooled in serum samples obtained from blood. Immediately after taken, the blood sample is kept at 37°C for 2 hours. Then it is centrifuged and the serum splits. It is kept at +4°C all night and the proteins settled in serum are evaluated.

Cryofibrinogen designation is the method of determining proteins that settle when cooled in plasma obtained from blood. Immediately after taken, the blood sample is kept at 37°C for 2 hours. Then it is centrifuged and the plasma splits. It is kept at +4°C all night and the proteins settled in serum are evaluated.

Considerations for cryoglobulin and cryofibrinogen analyses

For cryoglobulin test, 2 ml of blood sample is taken from patients into a simple, not including any anticoagulant (red covered) tube in the departments that they are examined. For cryofibrinogen test, 2 ml of blood sample is taken from patients into a tube with EDTA (purple covered), in the departments that they are examined. Immediately after the sample is taken, it should be carried in a thermos, which includes water heated until 37°C. Otherwise the sample is not admitted.

Sample admission is proceeded on every weekdays, except Fridays, between 08:00 and 12:00. The patient should apply to Basic Oncology Subdivision, with the routing documents received from the departments that the patients are examined.

Test result can be received from the secretariat of relevant division via hospital system or from the Secretariat of Basic Oncology Subdivision, after 14:00 on the next day.