A wide range of tests can be required for the diagnosis of blood diseases: Measuring the amount of blood cells and hemoglobin (complete blood count), analysis of subtypes of hemoglobin with electrophoresis, examining blood under a microscope (peripheral smear), examining bone marrow (bone marrow aspiration and biopsy) examining the levels of iron, vitamin B12 and folic acid required for blood formation, testing blood coagulation, tests related to the functions and the lifespan of blood cells, examining the proteins produced by immune system cells, analyzing blood cells or chromosomes and other components of the bone marrow cells which form blood cells and radiological examinations are the most frequently needed tests in Hematology.
The diagnosis services which are most frequently given in our department are microscopic examination of blood and bone marrow as well as tests for abnormalities in blood coagulation. 3 laboratories are affiliated to the department: Tests related to various diseases which progress with disruption in the coagulation of blood or increased coagulation are done in Coagulation-Hemostasis Laboratory. Coagulation-Hemostasis Laboratory provides service to all of Hacettepe Hospitals and also responds to the incoming test requests from other centers on a frequent basis. In addition to complete blood count, the samples of blood smears called peripheral smear, and bone marrows are stained in CBC and staining laboratory. Molecular genetic analyses related to various blood diseases are performed in PCR laboratory.
Diagnosis and treatment of any type of hematologic disease mentioned above can be performed through contemporary methods in Hematology Unit. Diagnoses and treatments of certain diseases require the patient to be hospitalized. Certain treatments such as intravascular administrations of medication and blood transfusion can also be performed in the outpatient treatment unit of our Outpatient Clinic. Hacettepe University Faculty of Medicine Hematology Unit is the center in which Allogeneic Bone Marrow Transplantation has been performed for the very first time in Turkey. Stem cell transplantation is still continued to be performed with success in our unit.
Tests Performed in Our Department
Coagulation Laboratory
Plasma Factor Tests
| Prothrombin time (INR) | ||
| Prothrombin time mix | Activated PTT (APTT) | Activated PTT mix |
| Fibrinogen C | Thrombin time (TT) | Antithrombin III (AT III) activity |
| D-dimer | Reptilase time | Factor II |
| Factor V | Factor VII | Factor VIII |
| Factor VIII inhibitor | Factor IX | Factor IX inhibitor |
| Factor X | Anti-factor Xa | Factor XI |
| Factor XIII | Lupus anticoagulant (PTT-LA) | Activated protein C resistance (APC) |
| Protein C activity | Free protein S | V.W.Factor Ristocetin cofactor (vWF:RCo) |
| V.Willebrand factor antigen (vWF:Ag) | Thrombin inhibitors | Plasminogen activity |
| Antiplasmin | TAFI | Plasma and complete blood viscosity |
Thrombocyte tests
PFA (in-vitro bleeding time)
Platelet Aggregation Test (service provided with appointment)
(ADP, Epinephrine, Collagen, Ristocetin)
Thromboelastography (TEG)
ASA (Aspirin resistance) test
HIT PF4
Peripheral Smear Laboratory
Peripheral smear
Iron stain (Hemosiderin) in urine
Iron stain in bone marrow
As of 2000, the external quality control of our laboratory has been conducted by UKNEQAS, an independent quality control body, and the internal quality control of our laboratory has been conducted by STAGO.